Speciality Organic Chemicals

Product Details:

Aloxistatin, also known as E-64d, is a synthetic cysteine protease inhibitor that primarily targets calpains and cathepsins. Its pharmacological mechanism involves the irreversible formation of a thioether bond with the active site of cysteine proteases, which modifies their activity and inhibits their function 34.

This drug has been investigated for various therapeutic applications, including neurodegeneration, cancer therapy, and as an antiviral agent. Specifically, Aloxistatin has shown potential in reducing the cellular entry of SARS-CoV-2 by inhibiting cathepsin L, which is crucial for the virus's entry into host cells 34. Additionally, it has been studied for its effects on muscular dystrophy, spinal cord injury, stroke, and Alzheimer's disease, although it has not been successful in human clinical trials for muscular dystrophy 34.

Furthermore, Aloxistatin has demonstrated anticoagulant effects and has been noted for its ability to inhibit hepatitis virus replication in animal models 34. Overall, Aloxistatin's diverse pharmacological properties make it a compound of interest in various fields of medical research.

Aloxistatin, also known as E-64d or loxistatin, is a synthetic cysteine protease inhibitor. Here are some key points regarding its characteristics and pharmacological profile:

• Mechanism of Action:
  Aloxistatin acts by irreversibly binding to the active site of cysteine proteases, such as calpains and cathepsins, through the formation of a thioether bond. This leads to the inhibition of the proteolytic activity of these enzymes.

• Therapeutic Uses:
  It has been explored in several therapeutic areas, including:

  • Neurodegeneration: Investigated for its potential to modulate protease activity implicated in neurodegenerative disorders.
  • Cancer Therapy: Considered for its regulatory effects on proteases that may play roles in cancer progression.
  • Antiviral Applications: Notably, it has shown promise in reducing the cellular entry of SARS-CoV-2 by targeting cathepsin L, an enzyme involved in viral entry into host cells.
  • Additional Areas:
    Other studies have looked into its potential in conditions such as muscular dystrophy, spinal cord injury, stroke, Alzheimer's disease, and even its anticoagulant properties, although not all of these have translated into successful human clinical outcomes.

• Research Context:
  Much of the research with Aloxistatin centers on its ability to modulate protease activity, which is why it's been a compound of interest for a variety of conditions where protease dysregulation plays a part. Its inhibitory effects on proteases like cathepsin L also position it as a candidate for antiviral strategies, particularly against viruses that utilize these proteases for entry or replication.

Overall, while promising in preclinical models, the efficacy and safety profile of Aloxistatin in human subjects have yet to be fully established for many of its proposed uses.

If you need further details or specific data, feel free to ask!

Feb 26, 01:44:52 PMJ

Additional Information:

• Production Capacity: 100 Kg
• Delivery Time: 30 days
• Packaging Details: HDPE Drum

Product Details:

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Product Details:

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