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4-Acetylbiphenyl (ACBP) is a biphenyl compound with various applications in research and synthesis. It's used as a probe molecule to study protein structure and function, as well as lipid membrane properties. Additionally, ACBP is used in the synthesis of Schiff's bases and to study enzyme inactivation.
Synthetic Applications:Schiff's Base Synthesis: ACBP can be employed in the preparation of Schiff's bases, which are important intermediates in organic synthesis. Building Block:ACBP can be prepared via Suzuki-Miyaura and Buchwald-Hartwig reactions, making it a useful building block for synthesizing more complex molecules. 

1-(3-Chlorophenyl)propan-1-one, also known as m-chloropropiophenone, is a ketone with a molecular formula of C9H9ClO. It's a biochemical reagent used in life science research and is also employed as a precursor in the synthesis of other compounds, including the drug bupropion

2-Bromo-3'-chloropropiophenone (BCP), 2B3C is a yellow oil with the chemical formula C9H8BrClO. It is an intermediate used in the synthesis of bupropion, a common antidepressant, and is also found as an impurity in bupropion hydrochloride. BCP has a CAS number of 34911-51-8 and a molecular weight of 247.52 g/mol. It is soluble in dichloromethane and has a boiling point of 295°C at 760 mm Hg. 

Chemical Name:2-Bromo-3'-chloropropiophenoneSynonyms2-BROMO-1-(3-CHLOROPHENYL)PROPAN-1-ONE;DK749;2B3CP;2-Bromo Bupropion;Bupropion Impurity 5;Bupropion Impurity 42;Bupropion impurity M1-9;Bromo Chloropropiophenone;Bupropion 2-BroMo IMpurity;Bupropion Related Compound GCBNumber:CB3271779Molecular Formula:C9H8BrClOMolecular Weight:247.52

Health Hazard

2-Bromo-3'-chloropropiophenone is irritating to the eyes, respiratory system, and skin.

Uses

2-Bromo-3'-chloropropiophenone is used as an important intermediate for raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.

Definition

2-Bromo-3'-chloropropiophenone (BCP), a yellow oil, is an intermediate used in the synthesis of bupropion and is also found as an impurity of bupropion hydrochloride. Bupropion is a second-generation antidepressant that was originally approved by the United States Food and Drug Administration (FDA) in 1985. It is a norepinephrine and dopamine transporter inhibitor and an antagonist at neuronal nicotinic acetylcholine receptors. Bupropion is also approved for smoking cessation[1].

Safety

The current United States Pharmacopeia (USP) specification is for no more than 0.1% BCP in the bupropion hydrochloride monograph. The Material Safety Data Sheet from a manufacturer indicates that BCP is irritating to the eyes, respiratory system, and skin. 2-Bromo-3'-chloropropiophenone was mutagenic with S9 metabolic activation, increasing the mutant frequencies in a concentration-dependent manner, up to 22- and 145-fold induction over the controls in Salmonella strains TA100 and TA1535, respectively. BCP was also positive in the in vitro micronucleus assay, resulting in up to 3.3- and 5.1-fold increase of micronucleus frequency for treatments in the absence and presence of S9, respectively; and 9.9- and 7.4-fold increase of aneuploidies without and with S9, respectively. The addition of N-acetyl-l-cysteine, an antioxidant, reduced the genotoxicity of BCP in both assays. Further studies showed that BCP treatment resulted in induction of reactive oxygen species (ROS) in the TK6 cells. The results suggest that BCP is mutagenic, clastogenic, and aneugenic, and that these activities are mediated via generation of reactive metabolites[1].

General Details

CAS number 100125-88-0 refers to 2-Bromo-4-ethylpropiophenone, also known as 2-bromo-1-(4-ethylphenyl)propan-1-one or 4'-Ethylphenacyl bromide. It is an aromatic ketone used as a chemical intermediate in organic synthesis, particularly in the pharmaceutical and fine chemical industries. Key characteristics:

• Chemical Formula: C11H13BrO
• Molecular Weight: 241.12
• Appearance: Can be a powder or liquid
• Function: Intermediates in organic synthesis
• Applications: Used in the production of pharmaceuticals and specialty chemicals 

Para Ethyl Propiophenone, P-Ethyl Propiophenone

4-Methylpropiophenone is an organic compound, specifically a ketone, used as a chemical intermediate in the synthesis of various pharmaceuticals and fine chemicals. It's known for its aromatic properties and is a precursor to active pharmaceutical ingredients (APIs) like naomaining. It also finds applications in fragrances and other industrial sectors. Key aspects:

Chemical Formula: C10H12O 

Molecular Weight: 148.2 g/mol 

Appearance: Typically a colorless to pale yellow liquid. 

Odor: Distinctive aromatic odor. 

Applications:

Pharmaceuticals: A key building block in the synthesis of various drugs, including naomaining. 

Fragrances: Used to impart aromatic qualities in fragrances. 

Other Industrial Uses: Acts as an intermediate in other industrial processes.

Propiophenone (also known as ethyl phenyl ketone or benzoylethane) is a colorless, sweet-smelling liquid that is insoluble in water but soluble in organic solvents.
 It is an aromatic ketone, meaning it contains a phenyl (benzene) ring and a carbonyl group (C=O) bonded to an ethyl group. Propiophenone is used as a fragrance and in the preparation of other compounds.